Flight 7500 departs Los Angeles International Airport bound for Tokyo. As the overnight flight makes its way over the Pacific Ocean during its ten-hour course, the passengers encounter what appears to be a supernatural force in the cabin.
In Tokyo, a young woman (Tamblyn) is exposed to the same mysterious curse that afflicted her sister (Gellar). The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.
American nurse, Karen Davis moves to Tokyo and encounters a vengeful supernatural spirit known as The Grudge that often possesses its victims. When a series of horrifying and mysterious deaths occur – with the spirit passing its curse onto each victim - Karen must find away to break the spell before she becomes the spirit's next victim.